On regulation of phagosome maturation and antigen presentation Review uri icon

Overview

MeSH Major

  • Antigen Presentation
  • Dendritic Cells
  • Phagocytosis
  • Phagosomes
  • Toll-Like Receptors

abstract

  • Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self-non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. An inducible mode of phagosome maturation triggered by these receptors ensures the selection of microbial antigens for presentation by major histocompatibility class II molecules during the simultaneous phagocytosis of self and non-self.

publication date

  • October 2006

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/ni1006-1029

PubMed ID

  • 16985500

Additional Document Info

start page

  • 1029

end page

  • 35

volume

  • 7

number

  • 10