Predictors of recurrence in patients with T2 and early T3, N0 adenocarcinoma of the rectum treated by surgery alone Academic Article uri icon


MeSH Major

  • Adenocarcinoma
  • Neoplasm Recurrence, Local
  • Rectal Neoplasms


  • Complete follow-up was available for all study patients. Median follow-up was 79.5 months (range, 57.7 to 105.9 months). During this time period 30 patients (31.9%) died as a result of disease and 64 patients (68.1%) remained alive and disease free. Five-year DSS was 73%. The cumulative risk for PR was 8% at 5 years and 10% at 8 years. Lymphovascular invasion, preoperative serum carcinoembryonic antigen (CEA > 5 ng/mL) level, and age older than 70 years were all associated with adverse outcome. CONCLUSION Patients with T2-3, N0 rectal cancers and either lymphovascular invasion or elevated CEA levels have reduced survival and a higher incidence of PR, and should be considered for future randomized trials.

publication date

  • September 2006



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2006.06.2968

PubMed ID

  • 16943525

Additional Document Info

start page

  • 4078

end page

  • 84


  • 24


  • 25