Opportunistic infections following related and unrelated T cell depleted bone marrow transplantation
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Leukemia, Myeloid, Acute
The infectious complicalioos of 338 recrpients of l T cell depleted bone ounow (mutant (TCD BMT) were analysed. AU marrows were TCD by soybean aggbtinin ml eep cd blood Us. Itonc wen HLA-riuuched siblings in 243 cases nd Dmbud HLA Hudofically matched or I antigen mis-matched in 95. AB patients with an undated donor or adnk patients with a related male donor or female donor >2S yean old, nceived anti-tfaymocyte globulin onia, secondary to CMV in 12 of 25. Oner pathogens induded AjperjDlu, adenovinis, RSV, toxoplasmosis, HHV-6, legionella, MAI, and/or PCP. The mortality associated wim opportunistic pneumonia was 30% among recipients of > related BMT, regardkasof ATO adininistnuion, conparcd to 100% for patients developing this complication following an undssed BMT. In addition to intentitial pneumonia, other opportunistic infections included CMV rcuiitis (n-3). M. HemopMIum of the skin (n-2). and EBV lymphoprolifesative disarden (n-24). The me of graft rejection infections. The mortality associated with these infections in unretad transplant recipients, despite anti-microbial therapy, demoosnie the need for novel approaches, such as adoptive immunotherapy, to improve their outcome.