Role of myosin light chain (MLC) phosphorylation in an-giotensin II (AII)-dependent enhancement of a-adrenoceptor-mediated contraction of rat tail artery smooth muscle cells Academic Article uri icon

Overview

MeSH Major

  • Cardiovascular Diseases
  • MicroRNAs

abstract

  • It is well established that MLC phosphorylation plays a key role in the regulation of smooth muscle contraction. It is also well established that All, and a number of other factors, at concentrations too low to initiate a direct contractile response, can enhance vascular smooth muscle contraction. We have previously shown that All can enhance the increase in Ca2+ i; the signal (measured with Fura 2) initiated by a-adrenoceptor agonists. We have also shown that the same low concentration of All can enhance phosphorylation of MLC without initiating a contraction of the tissue. In the present study we have investigated the dose dependency on the effects of All on MLC phosphorylation in rat tail artery tissues.

publication date

  • December 1997

Research

keywords

  • Academic Article

Additional Document Info

start page

  • 155

volume

  • 40