Cure of persistent, post-appendectomy Klebsiella pneumoniae septicaemia with continuous intravenous administration of meropenem Academic Article uri icon


MeSH Major

  • Anti-Bacterial Agents
  • Appendectomy
  • Appendicitis
  • Klebsiella Infections
  • Klebsiella pneumoniae
  • Postoperative Complications
  • Sepsis
  • Thienamycins


  • A 15-year-old girl developed a persistent bacteraemia with Klebsiella pneumoniae accompanied by systemic symptoms including high fever and rigors after appendectomy. Extensive laboratory and imaging work-up, including tests for an intra-vascular source of infection, did not reveal the origin of the persistent bacteraemia. The Klebsiella pneumoniae isolates were susceptible to gentamicin and colistin and intermediately susceptible to meropenem. The septicaemia persisted despite the intravenous administration of meropenem 1 g and later 2 g every 8 h in combination with intravenous gentamicin and later colistin. The patient was cured only after the continuous intravenous administration of meropenem of 6 g/d.

publication date

  • September 2006



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1080/00365540500504125

PubMed ID

  • 16938737

Additional Document Info

start page

  • 807

end page

  • 10


  • 38


  • 9