Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression Academic Article uri icon

Overview

MeSH Major

  • Gene Expression Regulation, Enzymologic
  • Herpesvirus 1, Human
  • Positron-Emission Tomography
  • Pyrimidine Nucleosides
  • Thymidine Kinase

abstract

  • Synthesis of three novel 2'-deoxy-2'-[18F]fluoro-1-beta-D-arabinofuranosyluracil derivatives [18F]FPAU, [18F]FBrVAU, and [18F]FTMAU is reported. The compounds were synthesized by coupling of 1-bromo-2-deoxy-2-fluoro sugars with corresponding silylated uracil derivatives. In vitro cell uptake indicated that all three compounds are taken up selectively in RG2TK+ cells with negligible uptake in RG2 cells. The results indicate that [18F]FBrVAU and [18F]FTMAU have better uptake profiles in comparison to [18F]FPAU and have potential as PET probes for imaging HSV1-tk gene expression.

publication date

  • August 24, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/jm0512847

PubMed ID

  • 16913728

Additional Document Info

start page

  • 5377

end page

  • 81

volume

  • 49

number

  • 17