T-cell prolymphocytic leukemia: An aggressive T cell malignancy with frequent cutaneous tropism Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Prolymphocytic
  • Leukemia, Prolymphocytic, T-Cell
  • Skin

abstract

  • T-PLL is a distinctive post-thymic T-cell malignancy with frequent cutaneous tropism. A diagnosis is possible in almost all cases based on characteristic clinical, light microscopic, phenotypic, and cytogenetic features. While a chromosome 14 inversion is highly characteristic, additional inherent cytogenetic differences, such as trisomy 8 with CMYC over-amplification, may account for some case to case variation in clinical course.

publication date

  • September 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2006.04.060

PubMed ID

  • 16908353

Additional Document Info

start page

  • 467

end page

  • 77

volume

  • 55

number

  • 3