Deciphering the export pathway of malaria surface proteins. Review uri icon

Overview

MeSH

  • Animals
  • Malaria, Falciparum
  • Protein Sorting Signals
  • Protein Transport
  • Virulence Factors

MeSH Major

  • Carrier Proteins
  • Erythrocytes
  • Membrane Proteins
  • Plasmodium falciparum
  • Protozoan Proteins

abstract

  • The intra-erythrocytic stages of Plasmodium falciparum assemble a unique protein trafficking system that targets parasite proteins to the red cell cytoplasm and cell surface. It is through this trafficking pathway that the primary virulence determinants of P. falciparum infections are targeted to the erythrocyte surface to mediate adhesion to host endothelial cells. A recent study has shown that SBP-1, a parasite protein associated with Maurer's clefts in the infected red cell cytosol, is essential for transport of the virulence factor PfEMP-1. This discovery sheds new light on the little-understood mechanisms that regulate protein trafficking in infected cells.

publication date

  • September 2006

has subject area

  • Animals
  • Carrier Proteins
  • Erythrocytes
  • Malaria, Falciparum
  • Membrane Proteins
  • Plasmodium falciparum
  • Protein Sorting Signals
  • Protein Transport
  • Protozoan Proteins
  • Virulence Factors

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.pt.2006.07.002

PubMed ID

  • 16843728

Additional Document Info

start page

  • 401

end page

  • 404

volume

  • 22

number

  • 9