Single-fiber electromyography shows terminal axon dysfunction in Miller Fisher syndrome: A case report Academic Article uri icon

Overview

MeSH Major

  • Axons
  • Miller Fisher Syndrome
  • Muscle Fibers, Skeletal

abstract

  • We studied a patient with ophthalmoparesis and pupillary areflexia 2 weeks after a viral syndrome. Miller Fisher syndrome was suspected but GQ1b antibodies were not detected. To define neuromuscular involvement we performed electrodiagnostic studies. Single-fiber electromyography (SFEMG) in the extensor digitorum communis (EDC) showed abnormal jitter and axonal blocking, suggesting terminal axon dysfunction. Subsequent GQ1b antibody titers were elevated to borderline levels. Clinical symptoms gradually resolved. SFEMG may help characterize neuropathies associated with antibodies to neuronal ganglioside and identify involvement of the terminal axon and neuromuscular junction.

publication date

  • August 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/mus.20544

PubMed ID

  • 16583369

Additional Document Info

start page

  • 232

end page

  • 4

volume

  • 34

number

  • 2