Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice Academic Article uri icon

Overview

MeSH Major

  • Anxiety
  • Cerebral Cortex
  • Receptor, Serotonin, 5-HT2A
  • Signal Transduction

abstract

  • Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment.

publication date

  • July 28, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1123432

PubMed ID

  • 16873667

Additional Document Info

start page

  • 536

end page

  • 40

volume

  • 313

number

  • 5786