Characteristics of patients with sensory neuropathy diagnosed with abnormal small nerve fibres on skin biopsy Academic Article uri icon

Overview

MeSH Major

  • Nerve Fibers
  • Neurons, Afferent
  • Peripheral Nervous System Diseases

abstract

  • Clinical, laboratory and electrodiagnostic (EDX) characteristics of 62 patients with sensory neuropathy with abnormal skin biopsies were reviewed. Reduced epidermal nerve fibre density (ENFD) was seen in 71% and morphological changes with normal ENFD were seen in 29% of the patients. Patients with small fibre sensory neuropathy may have associated large fibre loss undetected by routine EDX. Identified associations included abnormal glucose metabolism, Lyme vaccination, monoclonal gammopathy, vitamin B12 deficiency, coeliac disease, and diseases of the connective tissue, inflammatory bowel and thyroid. Sensory neuropathy remained undetermined in 50% of the patients.

publication date

  • August 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2077610

Digital Object Identifier (DOI)

  • 10.1136/jnnp.2006.091074

PubMed ID

  • 16844956

Additional Document Info

start page

  • 983

end page

  • 5

volume

  • 77

number

  • 8