Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum. Review uri icon

Overview

MeSH

  • Animals
  • Antigenic Variation
  • Antigens, Protozoan
  • Chromatin
  • DNA, Protozoan
  • Gene Silencing
  • Transcription, Genetic
  • Virulence

MeSH Major

  • Gene Expression Regulation
  • Genes, Protozoan
  • Plasmodium falciparum

abstract

  • The var gene family of the human malaria parasite Plasmodium falciparum remains a topic of intense research focus due to the key role these antigen-encoding genes play in the ability of parasites to cause disease and avoid the human immune response. In recent years, as molecular tools for investigating the mechanisms that coordinate var gene expression have become more sophisticated, numerous insights have been acquired into how parasites manage to regulate transcription of this large gene family such that only a single gene is expressed at a time. The results of different experimental approaches have implicated mechanisms of chromatin modification, subnuclear localisation, promoter/promoter interactions and sterile RNAs in the silencing and activation of individual var genes, however, the roles that each of these different aspects play remain ill defined. In addition, some conflicting data regarding silencing and monoallelic expression of recombinant var promoters have recently been published, thus adding to the difficulty of understanding this complex phenomenon. In this review, we hope to present some of the existing data regarding this controversial topic in a way that will be both informative and constructive in our efforts to understand the molecular aspects of antigenic variation by malaria parasites.

publication date

  • August 2006

has subject area

  • Animals
  • Antigenic Variation
  • Antigens, Protozoan
  • Chromatin
  • DNA, Protozoan
  • Gene Expression Regulation
  • Gene Silencing
  • Genes, Protozoan
  • Plasmodium falciparum
  • Transcription, Genetic
  • Virulence

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ijpara.2006.05.007

PubMed ID

  • 16797552

Additional Document Info

start page

  • 975

end page

  • 985

volume

  • 36

number

  • 9