Touched and moved by STAT3. Review uri icon

Overview

MeSH Major

  • Cell Movement
  • STAT3 Transcription Factor

abstract

  • STAT3, a member of the signal transducer and activator of transcription (STAT) family of transcription factors, is a known regulator of cell motility through its transcriptional activating functions. However, new evidence suggests a novel role for non-tyrosine-phosphorylated and cytoplasmically localized STAT3 in mediating cell migration by disrupting an interaction between microtubules and one of its partners, stathmin. The association of STAT3 with stathmin potentiates microtubule polymerization and cell movement.

publication date

  • July 10, 2006

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/stke.3432006pe30

PubMed ID

  • 16835434

Additional Document Info

start page

  • pe30

volume

  • 2006

number

  • 343