Novel therapies for heart failure: focus on anti-inflammatory strategies. Review uri icon

Overview

MeSH Major

  • Anti-Inflammatory Agents
  • Heart Failure
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Plasmapheresis

abstract

  • The understanding of the pathomechanisms leading to heart failure has evolved from the simplistic pump-failure concept to the more complex syndrome involving neurohormonal and inflammatory systems. Anti-inflammatory therapy targeting specific cytokines, however, such as tumor necrosis factor-alpha, has failed to show clinical benefit. As a result, the focus has turned toward more broad-spectrum anti-inflammatory strategies. This review examines the various broad-spectrum anti-inflammatory modalities that have been used in heart failure: IV immunoglobulin administration, immune modulation therapy, immune adsorption, and plasmapheresis.

publication date

  • May 2006

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 16760701

Additional Document Info

start page

  • 153

end page

  • 9; quiz 160-1

volume

  • 12

number

  • 3