Intracellular sterol transport and distribution Review uri icon

Overview

MeSH Major

  • Carrier Proteins
  • Intracellular Membranes
  • Sterols

abstract

  • Sterols are important components of many biological membranes, and changes in sterol levels can have dramatic effects on membrane properties. Sterols are transported rapidly between cellular organelles by vesicular and nonvesicular processes. Recent studies have identified transmembrane proteins that facilitate the removal of sterols from membranes as well as soluble cytoplasmic proteins that play a role in their movement through the cytoplasm. The mechanisms by which these proteins work are generally not well understood. Cells maintain large differences in the sterol:phospholipid ratio in different organelles. Recent theoretical and experimental studies indicate ways in which the lipid environment can alter the chemical potential of sterols, which may help to explain aspects of their transport kinetics and distribution.

publication date

  • August 2006

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ceb.2006.06.012

PubMed ID

  • 16806879

Additional Document Info

start page

  • 379

end page

  • 85

volume

  • 18

number

  • 4