In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. Academic Article Article uri icon

Overview

MeSH

  • Humans
  • Phosphorus
  • Reproducibility of Results
  • Sensitivity and Specificity
  • United States

MeSH Major

  • Diagnosis, Computer-Assisted
  • Magnetic Resonance Spectroscopy
  • Neoplasms
  • Phosphorus Compounds
  • Tumor Markers, Biological

abstract

  • The standardization and reproducibility of techniques required to acquire anatomically localized 31P MR spectra non-invasively while studying tumors in cancer patients in a multi-institutional group at 1.5 T are reported. This initial group of patients was studied from 1995 to 2000 to test the feasibility of acquiring in vivo localized 31P MRS in clinical MR spectrometers. The cancers tested were non-Hodgkin's lymphomas, sarcomas of soft tissue and bone, breast carcinomas and head and neck carcinomas. The best accrual and spectral quality were achieved with the non-Hodgkin's lymphomas. The initial analysis of the spectral values of the sum of phosphoethanolamine plus phosphocholine normalized by the content of nucleotide triphosphates in a homogeneous sample of 32 NHL patients studied by in vivo (31)P MRS showed good reproducibility among different institutions. No statistical differences were found between the institution with the largest number of cases accrued and the rest of the multi-institutional NHL data (2.28 +/- 0.64, mean +/- standard error; n = 17, vs 2.08 +/- 0.14, n = 15). The preliminary data reported demonstrate that the institutions involved in this trial are obtaining reproducible 31P MR spectroscopic data non-invasively from human tumors. This is a fundamental prerequisite for the international cooperative group to be able to demonstrate the clinical value of the normalized determination of phosphoethanolamine plus phosphocholine by 31P MRS as predictor for treatment response in cancer patients. Copyright 2006 John Wiley & Sons, Ltd.

publication date

  • June 2006

has subject area

  • Diagnosis, Computer-Assisted
  • Humans
  • Magnetic Resonance Spectroscopy
  • Neoplasms
  • Phosphorus
  • Phosphorus Compounds
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tumor Markers, Biological
  • United States

Research

keywords

  • Clinical Trial
  • Journal Article
  • Multicenter Study

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/nbm.1057

PubMed ID

  • 16763965

Additional Document Info

start page

  • 504

end page

  • 512

volume

  • 19

number

  • 4