Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18 Academic Article uri icon

Overview

MeSH Major

  • Interleukin-12
  • Interleukin-18
  • Interleukins
  • Leishmania donovani
  • Leishmaniasis, Visceral

abstract

  • Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18(-/-) mice compared to wild-type mice and in IL-12p40(-/-) compared to IL-12p35(-/-) mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishmanial effects independent of IL-12.

publication date

  • July 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1489747

Digital Object Identifier (DOI)

  • 10.1128/IAI.00422-06

PubMed ID

  • 16790814

Additional Document Info

start page

  • 4370

end page

  • 4

volume

  • 74

number

  • 7