Molecular design and chemical synthesis of a highly potent epothilone Academic Article uri icon

Overview

MeSH Major

  • Epothilones

abstract

  • De novo designed and synthesized methylthiopyrazole epothilone B boasts a stunning biological profile against tumor cells, with activity at sub-nanomolar (IC50 = 0.06 nM) concentrations. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

publication date

  • January 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cmdc.200500056

PubMed ID

  • 16892332

Additional Document Info

start page

  • 41

end page

  • 4

volume

  • 1

number

  • 1