Ras, PI(3)K and mTOR signalling controls tumour cell growth Review uri icon

Overview

MeSH Major

  • Neoplasms
  • Phosphatidylinositol 3-Kinases
  • Protein Kinases
  • Signal Transduction
  • ras Proteins

abstract

  • All eukaryotic cells coordinate cell growth with the availability of nutrients in their environment. The mTOR protein kinase has emerged as a critical growth-control node, receiving stimulatory signals from Ras and phosphatidylinositol-3-OH kinase (PI(3)K) downstream from growth factors, as well as nutrient inputs in the form of amino-acid, glucose and oxygen availability. Notably, components of the Ras and PI(3)K signalling pathways are mutated in most human cancers. The preponderance of mutations in these interconnected pathways suggests that the loss of growth-control checkpoints and promotion of cell survival in nutrient-limited conditions may be an obligate event in tumorigenesis.

publication date

  • May 25, 2006

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nature04869

PubMed ID

  • 16724053

Additional Document Info

start page

  • 424

end page

  • 30

volume

  • 441

number

  • 7092