Reply Letter uri icon


MeSH Major

  • Carcinoma, Squamous Cell
  • Chromosome Aberrations
  • Gene Rearrangement
  • Head and Neck Neoplasms
  • Karyotyping
  • Spectrometry, Fluorescence
  • Translocation, Genetic


  • Accurately locating epileptic foci has great importance in advancing the treatment of epilepsy. In this study, epileptic seizures were first induced by intracortical injection of 4-aminopyridine in rats. A fluorescent deoxyglucose substitute, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG), was then continuously injected via the tail vein. Brain glucose metabolism was subsequently monitored by fluorescence imaging of 2-NBDG. The initial uptake rate of 2-NBDG at the injection site of 4-aminopyridine significantly exceeded that of the control injection site, which indicated local hypermetabolism induced by seizures. Our results show that 2-NBDG can be used for localizing epileptic foci.

publication date

  • July 2006



  • Letter


Digital Object Identifier (DOI)

  • 10.1016/j.jamcollsurg.2006.04.001

Additional Document Info

start page

  • 136

end page

  • 40


  • 203


  • 1