Expression of estrogen receptors-α and -β in bladder cancer cell lines and human bladder tumor tissue
Carcinoma, Transitional Cell
Estrogen Receptor alpha
Gene Expression Regulation, Neoplastic
Urinary Bladder Neoplasms
ERbeta is the dominant receptor expressed in bladder cancer cell lines and in the majority of human bladder tumors. Moreover, the degree of ERbeta expression increases with increasing stage and grade of differentiation. Antiestrogens have an inhibitory effect on the growth of bladder cancer cells in vitro.