ONTOFUSION: ontology-based integration of genomic and clinical databases. Academic Article uri icon

Overview

MeSH

  • Data Collection
  • Database Management Systems
  • Humans
  • User-Computer Interface

MeSH Major

  • Databases, Factual
  • Databases, Genetic
  • Medical Informatics

abstract

  • ONTOFUSION is an ontology-based system designed for biomedical database integration. It is based on two processes: mapping and unification. Mapping is a semi-automated process that uses ontologies to link a database schema with a conceptual framework-named virtual schema. There are three methodologies for creating virtual schemas, according to the origin of the domain ontology used: (1) top-down--e.g. using an existing ontology, such as the UMLS or Gene Ontology--, (2) bottom-up--building a new domain ontology-- and (3) a hybrid combination. Unification is an automated process for integrating ontologies and hence the database to which they are linked. Using these methods, we employed ONTOFUSION to integrate a large number of public genomic and clinical databases, as well as biomedical ontologies.

publication date

  • July 2006
  • August 2006

has subject area

  • Data Collection
  • Database Management Systems
  • Databases, Factual
  • Databases, Genetic
  • Humans
  • Medical Informatics
  • User-Computer Interface

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.compbiomed.2005.02.004

PubMed ID

  • 16144697

Additional Document Info

start page

  • 712

end page

  • 730

volume

  • 36

number

  • 7-8