5-Aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine Academic Article uri icon

Overview

MeSH Major

  • 6-Mercaptopurine
  • Anti-Inflammatory Agents, Non-Steroidal
  • Azathioprine
  • Immunosuppressive Agents
  • Inflammatory Bowel Diseases
  • Mesalamine
  • Thioguanine

abstract

  • We found that 5-ASA therapy is associated with higher 6-TGn levels in children and adults with IBD on 6-MP/AZA. TPMT inhibition may not explain this effect because 5-ASA exposure did not affect 6-MMP levels. The observed association of CD with higher 6-TGn levels is novel and needs to be verified in prospective studies.

publication date

  • April 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/01.MIB.0000206544.05661.9f

PubMed ID

  • 16633046

Additional Document Info

start page

  • 251

end page

  • 7

volume

  • 12

number

  • 4