A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice Academic Article uri icon

Overview

MeSH Major

  • Lipopolysaccharides
  • Peptide Fragments
  • Pneumonia
  • Transglutaminases

abstract

  • Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-alpha-immunoreactive protein in lung homogenates and significantly decreased TNF-alpha-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

publication date

  • January 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1080/01902140600691514

PubMed ID

  • 16809220

Additional Document Info

start page

  • 43

end page

  • 53

volume

  • 32

number

  • 1-2