A Peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice. Academic Article uri icon

Overview

MeSH

  • Administration, Inhalation
  • Animals
  • Enzyme Activation
  • Enzyme Inhibitors
  • Interleukin-6
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neutrophils
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha

MeSH Major

  • Lipopolysaccharides
  • Peptide Fragments
  • Pneumonia
  • Transglutaminases

abstract

  • Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-alpha-immunoreactive protein in lung homogenates and significantly decreased TNF-alpha-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

publication date

  • February 2006
  • January 2006

has subject area

  • Administration, Inhalation
  • Animals
  • Enzyme Activation
  • Enzyme Inhibitors
  • Interleukin-6
  • Lipopolysaccharides
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neutrophils
  • Peptide Fragments
  • Pneumonia
  • RNA, Messenger
  • Transglutaminases
  • Tumor Necrosis Factor-alpha

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1080/01902140600691514

PubMed ID

  • 16809220

Additional Document Info

start page

  • 43

end page

  • 53

volume

  • 32

number

  • 1-2