Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals Academic Article uri icon

Overview

MeSH Major

  • Angiotensin II
  • Cerebrovascular Circulation
  • Endothelium, Vascular
  • Reactive Oxygen Species

abstract

  • Ang II impairs the endothelial regulation of the cerebral microcirculation through AT1 receptor-mediated cerebrovascular oxidative stress. The source of the ROS is a nox-2-containing NADPH oxidase. These effects of Ang II could threaten the cerebral blood supply and contribute to the increased susceptibility to stroke and dementia associated with hypertension.

publication date

  • April 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.ATV.0000205849.22807.6e

PubMed ID

  • 16439707

Additional Document Info

start page

  • 826

end page

  • 32

volume

  • 26

number

  • 4