Cerebrospinal fluid biomarkers for mild cognitive impairment Report uri icon

Overview

MeSH Major

  • Alzheimer Disease
  • Amyloid
  • Brain
  • Cognition Disorders
  • Positron-Emission Tomography

abstract

  • This article discusses the current knowledge on the most promising cerebrospinal fluid diagnostic biomarkers for mild cognitive impairment and early Alzheimer's disease. The considered biomarkers include total and phosphorylated Tau proteins, 40- and 42-residue forms of amyloid β and isoprostanes. Both the biological rationales and validation histories for each of the cerebrospinal fluid biomarkers are briefly presented and clinical results from relevant studies in the field are discussed. Comments on issues related to the cerebrospinal fluid clearance kinetics and how this may affect detection of the biomarkers in the cerebrospinal fluid are also presented. The concept of mild cognitive impairment and current views on this potential stage of the transition from normal aging to Alzheimer's disease and to other dementias are also discussed. Future perspectives, including limitations in identifying reliable, sensitive and specific mild cognitive impairment/Alzheimer's disease biomarkers, are presented. © 2006 Future Medicine Ltd.

publication date

  • February 2006

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.2217/1745509X.2.1.111

Additional Document Info

start page

  • 111

end page

  • 121

volume

  • 2

number

  • 1