Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response Academic Article uri icon

Overview

MeSH Major

  • Gene Amplification
  • Glioblastoma
  • Receptor, Epidermal Growth Factor
  • Xenograft Model Antitumor Assays

abstract

  • Our results indicate that EGFR amplification, as a biomarker, is not singularly predictive of glioblastoma response to radiation therapy, nor does the inhibition of EGFR enhance the intrinsic radiation responsiveness of glioblastoma tumors. However, efficacious EGFR inhibitor and radiation monotherapy regimens can be used in combination to achieve additive antitumor effect against a subset of glioblastoma.

publication date

  • April 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-05-2510

PubMed ID

  • 16609043

Additional Document Info

start page

  • 2264

end page

  • 71

volume

  • 12

number

  • 7 I