Ten-year results of preoperative radiation followed by sphincter preservation for rectal cancer: Increased local failure rate in nonresponders
Digestive System Surgical Procedures
This approach provides excellent long-term results in all patients with cT2 disease and those with cT3 disease that is downstaged by RT. However, patients with cT3 disease that is not downstaged by RT have an increased risk of local failure. These data underscore the impact of tumor response to radiation on long-term oncologic outcome.