Immunodeficiency in the lupus clinic Article Conference Paper uri icon


MeSH Major

  • Genetic Testing
  • High-Throughput Nucleotide Sequencing
  • Polycystic Kidney, Autosomal Dominant


  • Systemic lupus erythematous (SLE) and immunodeficiency are linked in various ways. For example, rare genetic complement deficiencies can pre-dispose to developing SLE, whilst some treatments for SLE can cause secondary immunodeficiencies. Various case reports describe SLE patients who have concomitant or later develop antibody deficiency, possibly related to immunosuppressive treatment, or possibly related to the lupus itself. Other components of the immune system, innate and adaptive may also be affected. Immunosuppressive treatment may also cause infections in the absence of defects on routine immunological testing. It is important for the clinician to be aware of the associations between SLE and immunodeficiency to ensure optimal investigation and management. This review focuses on aspects of humoral and cellular immunity, and their association with SLE. © 2006 Edward Arnold (Publishers) Ltd.

publication date

  • May 2006



  • Conference Paper


Digital Object Identifier (DOI)

  • 10.1191/0961203306lu2282rr

PubMed ID

  • 16634364

Additional Document Info

start page

  • 127

end page

  • 131


  • 15


  • 3