Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Genes, erbB-1
  • Lung Neoplasms
  • Mutation
  • Smoking

abstract

  • The likelihood of EGFR mutations in exons 19 and 21 decreases as the number of pack-years increases. Mutations were less common in people who smoked for more than 15 pack-years or who stopped smoking cigarettes less than 25 years ago. These data can assist clinicians in assessing the likelihood of exon 19 and 21 EGFR mutations in patients with lung adenocarcinoma when mutational analysis is not feasible.

publication date

  • April 10, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2005.04.3224

PubMed ID

  • 16505411

Additional Document Info

start page

  • 1700

end page

  • 4

volume

  • 24

number

  • 11