Transfer characteristics of the hair cell's afferent synapse Academic Article uri icon

Overview

MeSH Major

  • Hair Cells, Auditory
  • Neurons, Afferent
  • Synapses

abstract

  • The sense of hearing depends on fast, finely graded neurotransmission at the ribbon synapses connecting hair cells to afferent nerve fibers. The processing that occurs at this first chemical synapse in the auditory pathway determines the quality and extent of the information conveyed to the central nervous system. Knowledge of the synapse's input-output function is therefore essential for understanding how auditory stimuli are encoded. To investigate the transfer function at the hair cell's synapse, we developed a preparation of the bullfrog's amphibian papilla. In the portion of this receptor organ representing stimuli of 400-800 Hz, each afferent nerve fiber forms several synaptic terminals onto one to three hair cells. By performing simultaneous voltage-clamp recordings from presynaptic hair cells and postsynaptic afferent fibers, we established that the rate of evoked vesicle release, as determined from the average postsynaptic current, depends linearly on the amplitude of the presynaptic Ca(2+) current. This result implies that, for receptor potentials in the physiological range, the hair cell's synapse transmits information with high fidelity.

publication date

  • April 4, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1414630

Digital Object Identifier (DOI)

  • 10.1073/pnas.0601103103

PubMed ID

  • 16567618

Additional Document Info

start page

  • 5537

end page

  • 42

volume

  • 103

number

  • 14