Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications Academic Article uri icon

Overview

MeSH Major

  • Angiotensin II
  • Diabetic Angiopathies
  • Glycosylation End Products, Advanced
  • Serine Endopeptidases

abstract

  • AGEs, a hallmark of diabetes, induce chymase via the RAGE-ERK1/2 MAP kinase pathway. Chymase initiates an important alternative angiotensin II-generating pathway in diabetes and may play a critical role in diabetic vascular disease.

publication date

  • March 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1401500

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.105.575589

PubMed ID

  • 16520412

Additional Document Info

start page

  • 1353

end page

  • 60

volume

  • 113

number

  • 10