Benzoylphenylurea sulfur analogues with potent antitumor activity Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Phenylurea Compounds
  • Pyrimidines

abstract

  • A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was more effective than 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC(50) of 2.1 microM.

publication date

  • April 6, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/jm051261s

PubMed ID

  • 16570932

Additional Document Info

start page

  • 2357

end page

  • 60

volume

  • 49

number

  • 7