Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma Academic Article uri icon

Overview

MeSH Major

  • Cornea
  • Disease Models, Animal
  • Glaucoma, Angle-Closure
  • Intraocular Pressure
  • Optic Nerve Diseases

abstract

  • IOP increased with age in most, but not all, DBA/2 mice. In age-matched mice, differences in IOP corresponded to differences in axonal density and number. In young mice with elevated IOP, the loss of axons resembled that of older animals with similar IOP. Whether corneal thickness is a byproduct of elevated IOP remains unknown, but it may be useful as an index of optic nerve degeneration.

publication date

  • March 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1167/iovs.05-0925

PubMed ID

  • 16505033

Additional Document Info

start page

  • 986

end page

  • 96

volume

  • 47

number

  • 3