Antigenic variation by protozoan parasites: insights from Babesia bovis. Academic Article uri icon

Overview

MeSH

  • Animals
  • Antigens, Protozoan
  • Cattle
  • Genes, Protozoan

MeSH Major

  • Antigenic Variation
  • Babesia bovis

abstract

  • Antigenic variation of surface membrane proteins by protozoan parasites enables these pathogenic organisms to avoid host immune responses and thus perpetuate long-term infections. Babesia bovis, the causative agent of severe babesiosis in cattle, was previously shown to undergo antigenic variation through modifications to its primary surface antigen, a protein called VESA1. In this issue, Al-Khedery and Allred provide a detailed description of the genes that encode VESA1 and present convincing evidence for progressive, segmental gene conversion in the generation of variant forms of this surface antigen.

publication date

  • January 2006

has subject area

  • Animals
  • Antigenic Variation
  • Antigens, Protozoan
  • Babesia bovis
  • Cattle
  • Genes, Protozoan

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2958.2005.05007.x

PubMed ID

  • 16390434

Additional Document Info

start page

  • 364

end page

  • 366

volume

  • 59

number

  • 2