Hyperchromatic crowded groups in cervical cytology - Differing appearances and interpretations in conventional and ThinPrep preparations: A study from the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology
Carcinoma, Squamous Cell
Cervical Intraepithelial Neoplasia
Uterine Cervical Neoplasms
Hyperchromatic crowded groups of cells are a source of difficulty in challenging HSIL cases for both conventional smears and ThinPrep specimens. In conventional smears, these groups are more likely to be labeled as a squamous lesion, owing to their elongate and large nuclei. In ThinPrep specimens, however, these groups are more likely to be labeled as glandular lesions, owing to their smooth contoured borders and small nuclei.