The management of superficial transitional cell carcinoma of the bladder Review uri icon


MeSH Major

  • Carcinoma, Transitional Cell
  • Urinary Bladder Neoplasms


  • Superficial transitional cell carcinomas (TCC) of the urinary bladder, defined as those that are restricted to the mucosa or the lamina propria, represent a common condition with a wide spectrum of biologic significance. High-grade superficial TCC, particularly in the presence of lamina propria invasion, has a significant risk of occult or subsequent progression to muscle-invasive or metastatic disease. Such high-risk lesions merit aggressive therapy with repeat resection followed by intravesical therapy, usually in the form of bacille Calmette-GuĂ©rin. Criteria for failure of intravesical therapy are not well defined, but persistent cytologic or cystoscopic abnormalities at 6 months are worrisome. Salvage intravesical therapy may sometimes be successful, but early cystectomy should be strongly considered, especially in younger patients. Close surveillance of patients with high-risk superficial TCC is essential.

publication date

  • March 2006



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.urology.2006.01.041

PubMed ID

  • 16530076

Additional Document Info

start page

  • 48

end page

  • 54; discussion 54-5


  • 67


  • 3 SUPPL. 1