Activation of the Cbl insulin signaling pathway in cardiac muscle; Dysregulation in obesity and diabetes Academic Article uri icon


MeSH Major

  • Diabetes Mellitus
  • Insulin
  • Myocardium
  • Obesity
  • Proto-Oncogene Proteins c-cbl
  • Signal Transduction


  • In adipocytes, the Cbl/CAP dependent signaling pathway has been involved in regulating insulin-stimulated glucose uptake. We investigated activation of Cbl and its downstream effector TC10 in cardiac and skeletal muscle of Balb/C mice. Insulin administration resulted in Cbl phosphorylation in cardiac, skeletal muscle, and adipose tissue. Subsequent TC10 activation was detected only in heart and adipose tissue. c-Cbl and CAP gene expression was significantly reduced in the heart tissue of streptozotocin-induced diabetic animals, whereas no change was observed for other components of the pathway. No changes in Cbl expression were detected in hindlimb muscle. In leptin-/- obese mice Cbl expression in heart and adipose tissue was maintained, although insulin-mediated Cbl phosphorylation and subsequent TC10 activation were significantly reduced. In conclusion, our data demonstrate that Cbl/CAP/TC10 insulin signaling pathway is active in cardiac muscle and impaired during obesity and insulin deficiency.

publication date

  • April 14, 2006



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2006.02.023

PubMed ID

  • 16494846

Additional Document Info

start page

  • 751

end page

  • 7


  • 342


  • 3