Contrast-Enhanced Mammography for Screening Women after Breast Conserving Surgery. Academic Article uri icon

Overview

abstract

  • To investigate the value of contrast-enhanced mammography (CEM) compared to full-field digital mammography (FFDM) in screening breast cancer patients after breast-conserving surgery (BCS), this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved retrospective, single-institution study included 971 CEM exams in 541 asymptomatic patients treated with BCS who underwent screening CEM between January 2013 and November 2018. Histopathology, or at least a one-year follow-up, was used as the standard of reference. Twenty-one of 541 patients (3.9%) were diagnosed with ipsi- or contralateral breast cancer: six (28.6%) cancers were seen with low-energy images (equivalent to FFDM), an additional nine (42.9%) cancers were detected only on iodine (contrast-enhanced) images, and six interval cancers were identified within 365 days of a negative screening CEM. Of the 10 ipsilateral cancers detected on CEM, four were detected on low-energy images (40%). Of the five contralateral cancers detected on CEM, two were detected on low-energy images (40%). Overall, the cancer detection rate (CDR) for CEM was 15.4/1000 (15/971), and the positive predictive value (PPV3) of the biopsies performed was 42.9% (15/35). For findings seen on low-energy images, with or without contrast, the CDR was 6.2/1000 (6/971), and the PPV3 of the biopsies performed was 37.5% (6/16). In the post-BCS screening setting, CEM has a higher CDR than FFDM.

authors

  • Gluskin, Jill
  • Rossi Saccarelli, Carolina
  • Avendano, Daly
  • Marino, Maria Adele
  • Bitencourt, Almir G V
  • Pilewskie, Melissa
  • Sevilimedu, Varadan
  • Sung, Janice S
  • Pinker, Katja
  • Jochelson, Maxine S

publication date

  • November 24, 2020

Identity

PubMed Central ID

  • PMC7760311

Scopus Document Identifier

  • 85096664650

Digital Object Identifier (DOI)

  • 10.3390/cancers12123495

PubMed ID

  • 33255412

Additional Document Info

volume

  • 12

issue

  • 12