Antibody-Targeted Imaging of Gastric Cancer. Review uri icon

Overview

abstract

  • The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.

publication date

  • October 11, 2020

Research

keywords

  • Positron-Emission Tomography
  • Stomach Neoplasms
  • Tomography, Emission-Computed, Single-Photon

Identity

PubMed Central ID

  • PMC7587187

Scopus Document Identifier

  • 85092480507

Digital Object Identifier (DOI)

  • 10.3390/molecules25204621

PubMed ID

  • 33050602

Additional Document Info

volume

  • 25

issue

  • 20