Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma
Proto-Oncogene Proteins B-raf
In contrast to the majority of cutaneous melanomas, activating hot-spot mutations in B-RAF or N-RAS were not involved in the pathogenesis of Spitzoid melanoma. These data suggested that Spitzoid melanoma is a distinct form of melanoma with unknown genes and/or signaling pathways involved in its development.