Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease Academic Article uri icon

Overview

MeSH Major

  • Organotechnetium Compounds
  • Parkinson Disease
  • Radiopharmaceuticals
  • Tomography, Emission-Computed, Single-Photon
  • Tropanes

abstract

  • We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and anterior and posterior putamen (p < 0.0001) of PD patients compared to controls. Using the posterior putamen as the main region of interest resulted in the greatest accuracy (sensitivity 0.79, specificity 0.92). These findings show that TRODAT imaging can accurately differentiate early PD patients from controls and has the potential to improve the diagnosis of patients with early signs of PD.

publication date

  • August 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.parkreldis.2004.04.002

PubMed ID

  • 15261880

Additional Document Info

start page

  • 375

end page

  • 9

volume

  • 10

number

  • 6