Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C Academic Article uri icon

Overview

MeSH Major

  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins
  • Epithelial Cells
  • Mammary Glands, Human
  • Matrix Metalloproteinase 9
  • Trans-Activators

abstract

  • Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.

publication date

  • July 20, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC489981

Digital Object Identifier (DOI)

  • 10.1073/pnas.0404100101

PubMed ID

  • 15249664

Additional Document Info

start page

  • 10602

end page

  • 7

volume

  • 101

number

  • 29