A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery. Academic Article uri icon

Overview

abstract

  • Towards clinical translation of cancer nanomedicine, it is important to systematically investigate the various parameters related to nanoparticle (NP) physicochemical properties, tumor characteristics, and inter-individual variability that affect the tumor delivery efficiency of therapeutic nanomaterials. Comprehensive investigation of these parameters using traditional experimental approaches is impractical due to the vast parameter space; mathematical models provide a more tractable approach to navigate through such a multidimensional space. To this end, we have developed a predictive mathematical model of whole-body NP pharmacokinetics and their tumor delivery in vivo, and have conducted local and global sensitivity analyses to identify the factors that result in low tumor delivery efficiency and high off-target accumulation of NPs. Our analyses reveal that NP degradation rate, tumor blood viscosity, NP size, tumor vascular fraction, and tumor vascular porosity are the key parameters in governing NP kinetics in the tumor interstitium. The impact of these parameters on tumor delivery efficiency of NPs is discussed, and optimal values for maximizing NP delivery are presented.

publication date

  • February 29, 2020

Identity

PubMed Central ID

  • PMC7078505

Scopus Document Identifier

  • 85081650033

Digital Object Identifier (DOI)

  • 10.1016/j.csbj.2020.02.014

PubMed ID

  • 32206211

Additional Document Info

volume

  • 18