SnapShot: Splicing Alterations in Cancer. Academic Article uri icon

Overview

abstract

  • RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF.

publication date

  • January 9, 2020

Research

keywords

  • Alternative Splicing
  • Neoplasms
  • RNA Splice Sites

Identity

PubMed Central ID

  • PMC7291876

Scopus Document Identifier

  • 85077322780

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2019.12.011

PubMed ID

  • 31951519

Additional Document Info

volume

  • 180

issue

  • 1