Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model Academic Article uri icon

Overview

MeSH Major

  • Busulfan
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells
  • Transplantation Conditioning

abstract

  • We conclude that low-dose intravenous bolus infusion of busulfan is well tolerated, has dose-dependent effects on peripheral blood counts, and allows long-term engraftment of genetically modified cells, but at levels too low for most clinical disorders.

publication date

  • February 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2676898

Digital Object Identifier (DOI)

  • 10.1016/j.exphem.2005.10.010

PubMed ID

  • 16459181

Additional Document Info

start page

  • 132

end page

  • 9

volume

  • 34

number

  • 2