Maternal Fluoxetine Exposure Alters Cortical Hemodynamic and Calcium Response of Offspring to Somatosensory Stimuli. Academic Article uri icon

Overview

abstract

  • Epidemiological studies have found an increased incidence of neurodevelopmental disorders in populations prenatally exposed to selective serotonin reuptake inhibitors (SSRIs). Optical imaging provides a minimally invasive way to determine if perinatal SSRI exposure has long-term effects on cortical function. Herein we probed the functional neuroimaging effects of perinatal SSRI exposure in a fluoxetine (FLX)-exposed mouse model. While resting-state homotopic contralateral functional connectivity was unperturbed, the evoked cortical response to forepaw stimulation was altered in FLX mice. The stimulated cortex showed decreased activity for FLX versus controls, by both hemodynamic responses [oxyhemoglobin (HbO2)] and neuronal calcium responses (Thy1-GCaMP6f fluorescence). Significant alterations in both cortical HbO2 and calcium response amplitude were seen in the cortex ipsilateral to the stimulated paw in FLX as compared to controls. The cortical regions of largest difference in activation between FLX and controls also were consistent between HbO2 and calcium contrasts at the end of stimulation. Taken together, these results suggest a global loss of response signal amplitude in FLX versus controls. These findings indicate that perinatal SSRI exposure has long-term consequences on somatosensory cortical responses.

publication date

  • December 27, 2019

Research

keywords

  • Calcium
  • Evoked Potentials, Somatosensory
  • Fluoxetine
  • Hemodynamics
  • Prenatal Exposure Delayed Effects
  • Selective Serotonin Reuptake Inhibitors
  • Somatosensory Cortex

Identity

PubMed Central ID

  • PMC6978917

Scopus Document Identifier

  • 85077296942

Digital Object Identifier (DOI)

  • 10.1523/ENEURO.0238-19.2019

PubMed ID

  • 31843753

Additional Document Info

volume

  • 6

issue

  • 6