Relationship between diffusion capacity and small airway abnormality in COPDGene. uri icon

Overview

abstract

  • Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. TRIAL REGISTRATION: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.

publication date

  • December 2, 2019

Research

keywords

  • Airway Obstruction
  • Bronchioles
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Emphysema

Identity

PubMed Central ID

  • PMC6889734

Scopus Document Identifier

  • 85075914208

Digital Object Identifier (DOI)

  • 10.1164/ajrccm.158.3.9801045

PubMed ID

  • 31791337

Additional Document Info

volume

  • 20

issue

  • 1