Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism. Review uri icon

Overview

abstract

  • Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.

publication date

  • October 10, 2019

Research

keywords

  • Adaptive Immunity
  • Autoimmunity
  • Forkhead Transcription Factors
  • Inflammation
  • T-Lymphocytes, Regulatory

Identity

PubMed Central ID

  • PMC7657366

Scopus Document Identifier

  • 85077762097

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2019.09.010

PubMed ID

  • 31607562

Additional Document Info

volume

  • 31

issue

  • 1