Optimizing a novel regional chemotherapeutic agent against melanoma: Hyperthermia-induced enhancement of temozolomide cytotoxicity Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents, Alkylating
  • Chemotherapy, Cancer, Regional Perfusion
  • Dacarbazine
  • Hyperthermia, Induced
  • Melanoma, Experimental

abstract

  • This study, the first to examine the interaction between hyperthermia and temozolomide, shows a strong, synergistic antitumor effect when hyperthermia is combined with temozolomide for regional treatment of melanoma confined to an extremity. The mechanism of this synergy seems to be through an augmentation, by hyperthermia, of the antiproliferative and proapoptotic effects of temozolomide.

publication date

  • January 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-05-0210

PubMed ID

  • 16397054

Additional Document Info

start page

  • 289

end page

  • 97

volume

  • 12

number

  • 1